Bone marrow SELENOP+ macrophages support hematopoiesis after transplantation via GAS6-AXL signaling pathway - PubMed
3 hours ago
- #GAS6-AXL signaling
- #hematopoiesis
- #macrophages
- Bone marrow SELENOP+ macrophages support hematopoiesis after transplantation via the GAS6-AXL signaling pathway.
- Poor hematopoietic reconstitution (PHR) is a serious complication post-chemotherapy/radiotherapy with unclear pathogenesis.
- SELENOP+ macrophages exhibit an M2-biased phenotype and support hematopoietic stem cells (HSCs).
- These macrophages are impaired in patients with poor graft function (PGF) post-transplantation due to defective GAS6-AXL signaling.
- Reduced AXL activity leads to macrophage dysfunction and decreased IGF1 secretion.
- GAS6 treatment partially restores HSC-supporting ability in impaired macrophages from PGF patients.
- The study offers new therapeutic insights for impaired hematopoiesis.