Lysosomal down-regulation of the mu opioid receptor is opposed by the Retromer complex - PubMed
3 hours ago
- #mu opioid receptor
- #lysosomal down-regulation
- #Retromer complex
- Lysosomal down-regulation of the mu opioid receptor (MOR) is a key mechanism for regulating its activity.
- The Retromer complex opposes MOR lysosomal down-regulation by promoting its recycling from endosomes back to the plasma membrane.
- MOR accesses the Retromer recycling pathway through a noncanonical bileucine recycling motif.
- This recycling mechanism is crucial for MOR regulation following chronic opioid drug exposure.
- The bileucine pathway for Retromer-based recycling is also found in other membrane proteins, such as the glucose transporter GLUT4.