TNFSF13 insufficiency disrupts human colonic epithelial cell growth and associated B cell dynamics - PubMed
4 hours ago
- #TNFSF13
- #inflammatory bowel disease
- #colonic epithelium
- A novel monoallelic TNFSF13 variant reduces TNFSF13 secretion by over 50% in colonoids.
- TNFSF13 insufficiency increases epithelial proliferation and reduces apoptosis, confirmed in iPSC-derived colon organoids.
- FAS is identified as the main colonic epithelial receptor for TNFSF13, validated by co-immunoprecipitation and binding assays.
- TNFSF13 variant colon tissue shows increased epithelial-associated B cells, and coculture with memory B cells reduces plasma cell production.
- The findings reveal a role for epithelial TNFSF13 in regulating colonic epithelial growth and interactions with B cells.