The TGFB1-Wnt/β-catenin axis programs a neuroprotective IGF1+ microglial state during epileptogenesis - PubMed
7 hours ago
- #Epilepsy
- #Neuroprotection
- #Microglia
- Early-emerging microglial subpopulation characterized by high IGF1 expression identified via snRNA-seq in a seizure model.
- TGFB1 stimulation induces neuroprotective IGF1+ microglia, suppressing pro-inflammatory cytokines and enhancing neuronal survival.
- TGFB1 activates Wnt/β-catenin pathway, leading to β-catenin nuclear translocation and upregulation of IGF1; knockdown of β-catenin abolishes neuroprotective effects.
- Findings reveal TGFB1-β-catenin-IGF1 axis as a novel endogenous neuroprotective mechanism and potential therapeutic target for epilepsy.