Macrophage Membrane-Cloaked, ROS-Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome - PubMed
a day ago
- #PCOS
- #ROS-responsive
- #nanomedicine
- Engineered ROS-responsive, macrophage-membrane-camouflaged quercetin nanocarriers (MM@PCD@QNPs) for targeted PCOS treatment.
- Nanocarriers designed to release quercetin in response to elevated ROS levels, enhancing ovarian delivery and reducing toxicity.
- MM@PCD@QNPs demonstrated efficacy in promoting granulosa cell proliferation, reducing apoptosis, and lowering ROS in PCOS models.
- Mechanistic studies suggest activation of the MAPK7-Nrf2-NQO1 axis as key to the therapeutic effect.
- The approach addresses quercetin's low bioavailability and off-target exposure, offering a safer, effective nanotherapy for PCOS.