Repurposing dronedarone induces ferroptosis through GPX4 inactivation and degradation in pancreatic cancer - PubMed
2 hours ago
- #Pancreatic Cancer
- #Dronedarone
- #Ferroptosis
- Repurposing dronedarone induces ferroptosis in pancreatic cancer by inactivating and degrading GPX4.
- The study involves high-throughput screening and highlights the role of autophagy and ferroptosis in cancer treatment.
- Animal experiments were approved by the Animal Experimentation Ethics Committee of Lanzhou University Second Hospital.
- No competing interests were declared by the authors.
- References include studies on intratumoral microbiota, redox signaling in the pancreas, and mechanisms of ferroptosis.