Antidiabetic Drug Associations With Heart Failure Outcomes: Real-World Evidence Study Using Electronic Health Records - PubMed
3 hours ago
- #heart-failure
- #sulfonylureas
- #metformin
- Patients taking sulfonylureas after metformin had significantly higher 5-year heart failure-free survival compared to those on insulin (survival ratio 0.902, P=0.01), indicating lower HF risk.
- No significant difference in 5-year HF-free survival or hospitalization risk was found between GLP1 RA and DPP4i groups, suggesting similar HF outcomes for these therapies.
- Study limitations include potential confounding factors and a limited sample size, highlighting the need for careful interpretation of real-world evidence.