Endothelial SMAD1-MCAM axis facilitates sunitinib resistance and progression of clear cell renal cell carcinoma via LAMB1-ITGB1 signaling - PubMed
3 hours ago
- #Endothelial Cells
- #Metastasis
- #ccRCC
- Identified MCAM+ endothelial cells (MCAM+ ECs) in clear cell renal cell carcinoma (ccRCC) that promote disease progression.
- MCAM+ ECs facilitate metastasis via the LAMB1-ITGB1-RhoA signaling axis, contributing to EMT and extracellular matrix remodeling.
- SMAD1 regulates MCAM+ EC reprogramming by modulating MCAM and LAMB1 expression.
- Developed an MCAM+ EC-based Risk Score (MERS) for prognostic stratification of ccRCC patients.
- The SMAD1-MCAM-LAMB1-ITGB1-RhoA axis provides novel insights into metastatic mechanisms and potential therapeutic targets.