Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerbates starvation-induced hepatic steatosis - PubMed
3 hours ago
- #hepatic steatosis
- #FoxO signaling
- #muscle-liver axis
- Loss of FoxO transcription factors in skeletal muscle worsens starvation-induced hepatic steatosis by disrupting muscle metabolism.
- FoxO deficiency in skeletal muscle reduces fatty acid oxidation and increases abnormal glycogen accumulation during fasting.
- Skeletal muscle FoxOs regulate triglyceride lipase expression, which is attenuated in FoxO-deficient mice during starvation.
- Overexpression of FOXO1 in skeletal muscle increases triglyceride lipase levels and protects against Western diet-induced liver disease.
- The study highlights a critical liver-muscle signaling pathway involving FoxOs that influences liver pathophysiology during energy deprivation.