Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration - PubMed
4 hours ago
- #Notch signaling
- #tooth regeneration
- #ameloblast maturation
- Enamel is the hardest mineralized material in the human body but cannot regenerate once damaged.
- iPSC-derived secretory Ameloblasts (isAM) hold promise for tooth regeneration.
- Delta, a ligand for Notch receptor, is critical for ameloblast maturation.
- A soluble Notch agonist induces iAM organoid maturation without odontoblast interaction.
- Notch-activated iAM organoids can form enamel-like calcified material in vivo.
- DLX3 is required in human ameloblasts for the expression of key enamel proteins.
- The study presents a novel method for ameloblast maturation and enamel-like tissue formation.