Advances in the Therapeutic Landscape of Hepatocellular Carcinoma: Current Strategies and Future Perspectives - PubMed
3 hours ago
- #Precision Medicine
- #Immunotherapy
- #Hepatocellular Carcinoma
- Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major cause of cancer mortality worldwide.
- Treatment decisions for HCC must balance anticancer efficacy with preservation of liver function, portal hypertension control, and quality of life.
- Recent advances in HCC management include curative resection, ablation, transplantation, refined transarterial and radiotherapy techniques, and modern systemic therapy dominated by immunotherapy-based combinations.
- Challenges in HCC treatment include decision-making for patients with Child-Pugh B liver function, lack of robust predictive biomarkers, and resistance after initial response.
- Emerging tools like liquid biopsy, radiomics, AI-assisted imaging, and microbiome modulation may support future precision strategies and optimized treatment allocation.
- The review summarizes current evidence guiding staging and therapy selection, practical considerations across treatment modalities, and discusses evolving biomarkers and next-generation immunotherapy.