Treatment Effects on Chronic Active Lesions in Multiple Sclerosis: Current Evidence and Future Perspectives - PubMed
3 hours ago
- #Multiple Sclerosis
- #Neuroimaging
- #Chronic Active Lesions
- Chronic active lesions (CALs) in multiple sclerosis, including paramagnetic rim lesions, slowly expanding lesions, and TSPO-PET-positive lesions, are biomarkers for compartmentalized inflammation.
- Current disease-modifying therapies (DMTs) show limited and inconsistent short- to medium-term effects on CAL occurrence and evolution, though microstructural damage may be attenuated.
- Study challenges include cohort heterogeneity, imaging variability, short follow-ups, and partial biological overlap among CAL subtypes.
- Future research should use prospective, multimodal longitudinal designs with standardized protocols to better assess treatment impacts on smoldering MS.