Microbiome crosstalk and nutrition: the interplay between gut microbiota-organ axis and dietary factors - PubMed
7 hours ago
- #Gut Microbiota
- #Gut-Organ Axis
- #Nutrition
- The gut microbiota is considered a central organ that interacts with other organs via humoral, immunological, metabolic, endocrine, and neurological pathways.
- Imbalances in gut microbiota can lead to diseases beyond the gastrointestinal system, affecting the brain, liver, lungs, heart, mouth, and skin.
- Communication along the gut-organ axis involves mediators like short-chain fatty acids, microbial metabolites, neurotransmitters, cytokines, and hormonal signals.
- Dietary factors significantly influence gut microbiota-organ interactions, with nutritional supplements such as probiotics, prebiotics, synbiotics, vitamins, omega-3 fatty acids, and dietary fiber promoting balance.
- Consuming processed or red meat, high-fat, high-sugar, high-glycemic index foods, and excessive salt can disrupt microbiota balance, increasing systemic inflammation and disease risk.
- This review aims to explore how microbiome-targeted nutritional interventions can modulate gut-organ interactions to affect disease risk and metabolic homeostasis.