CSF microtubule-associated protein 1 light chain 3A and 3B levels are associated with tau pathology and Alzheimer's disease risk through amyloid deposition and microglial signaling - PubMed
5 days ago
- #Autophagy
- #Microglia
- #Alzheimer’s disease
- CSF microtubule-associated protein 1 light chain 3A and 3B levels are linked to tau pathology and Alzheimer's disease risk.
- The association is mediated through amyloid deposition and microglial signaling.
- The study received ethical approval from the Eisai Ethics Committee (2017-0433) and followed the Declaration of Helsinki.
- Written informed consent was obtained from all participants or their guardians.
- The authors declare no competing interests.
- The study references key literature on Alzheimer's disease, autophagy, and dementia prevention.
- Funding sources include the Anhui Provincial Department of Education and the Natural Science Foundation of China.