Tobacco Smoking and Lung Cancer Risk After Negative Baseline Low-Dose Computed Tomography Findings - PubMed
5 hours ago
- #LDCT screening
- #tobacco smoking
- #lung cancer
- Tobacco smoking is the primary risk factor for lung cancer (LC), the leading cause of cancer-related mortality worldwide.
- The study evaluated LC risk among individuals with negative baseline low-dose computed tomography (LDCT) findings, focusing on smoking status, pack-years, and cessation time.
- Smokers had a significantly higher LC risk than never smokers, especially those with ≥20 pack-years (e.g., ≥30 pack-years: AHR, 3.22).
- Elevated LC risk became significant 3 years after screening, with no increased risk observed at 2 years.
- A nonlinear dose-response relationship was found between pack-years and LC risk, with clinically relevant thresholds at ~20 pack-years.
- Females showed higher susceptibility to LC than males at comparable smoking exposure.
- Short-term smoking cessation (<15 years) did not significantly reduce LC risk.
- The findings support extending initial LDCT screening intervals and implementing personalized long-term monitoring based on smoking history.