Regulator of Calcineurin 1 Aggravates Tubular Epithelial Cell Injury in Diabetic Mice Through Promoting Liver Kinase B1 Ubiquitination - PubMed
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- #RCAN1
- #diabetic kidney disease
- #ubiquitination
- RCAN1 is upregulated in renal tubular epithelial cells (RTECs) in diabetic kidney disease (DKD) patients and mice.
- RCAN1 overexpression worsens mitochondrial damage and interstitial fibrosis in diabetic mice.
- RCAN1 reduces AMPK phosphorylation and activates the mTOR/PRAS40/S6K pathway, leading to lipid deposition.
- RCAN1 interacts with LKB1 and promotes its ubiquitination by inhibiting BAP1-mediated deubiquitination.
- RCAN1 disrupts the LKB1/AMPK pathway, contributing to tubular damage in RTECs under high glucose conditions.
- RCAN1 may serve as a potential therapeutic target for preventing DKD progression.