No-reflow phenomenon after vessel recanalization in acute ischemic stroke: mechanisms, diagnosis, and treatment directions - PubMed
10 hours ago
- #recanalization-therapy
- #ischemic-stroke
- #no-reflow-phenomenon
- The no-reflow phenomenon (NRP) is a condition where, despite successful recanalization of large vessels in acute ischemic stroke, microvascular tissue reperfusion remains impaired, leading to poor clinical outcomes.
- NRP prevalence after reperfusion therapy ranges from 3.3% to 63%, with mechanisms including intraluminal occlusion (e.g., distal embolization, microthrombus formation) and extraluminal constriction, along with inflammatory responses and neurovascular unit dysfunction.
- Diagnostic methods for NRP involve clinical, imaging, and other assessments, while explored treatments include targeted therapy, pericyte modulators, post-ischemic conditioning, and traditional Chinese medicine, aiming to improve patient management and guide future research.