Slm1, an F-BAR and PH domain-containing protein, regulates heat-induced turnover of nutrient transporter to control plasma-membrane quality - PubMed
5 hours ago
- #Heat Stress Response
- #Plasma Membrane Quality Control
- #Nutrient Transporter Turnover
- Slm1, an F-BAR and PH domain-containing protein in yeast, regulates plasma membrane quality control during heat stress by affecting the turnover of nutrient transporters.
- Overexpression of GFP-Slm1 leads to temperature sensitivity, abnormal actin organization, and defects in plasma membrane protein recycling, especially in eisosome-deficient cells.
- Excess Slm1 under heat stress selectively delays the endocytosis and vacuolar degradation of heat-damaged amino acid-polyamine-organocation (APC) transporters, causing prolonged accumulation at the plasma membrane.
- Eisosomes function to buffer against Slm1-driven defects in actin-dependent membrane trafficking, highlighting their role in stress adaptation and plasma membrane integrity.