Post-Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity - PubMed
7 hours ago
- #Post-translational modifications
- #CD8+ T cells
- #Tumor immunity
- CD8+ T cells are central to antitumor immunity, regulated by post-translational modifications (PTMs).
- PTMs like phosphorylation, ubiquitination, acetylation, methylation, and glycosylation influence CD8+ T cell activation, differentiation, and memory formation.
- Metabolism-responsive modifications such as lactylation link nutrient availability to T cell function.
- The tumor microenvironment (TME) alters PTM networks, leading to CD8+ T cell dysfunction and immune escape.
- Understanding PTMs in CD8+ T cells could enhance cancer immunotherapy by restoring their antitumor efficacy.