Amyloid-β as a target to suppress tonic PTH hypersecretion in hyperparathyroidism due to vitamin D deficiency - PubMed
3 hours ago
- #vitamin D deficiency
- #hyperparathyroidism
- #amyloid-β
- Hyperparathyroidism is linked to vitamin D deficiency, leading to increased parathyroid hormone (PTH) secretion.
- Amyloid-β peptide, derived from amyloid-β precursor protein (APP), is found in higher levels in hyperparathyroidism patients and aging mice with vitamin D deficiency.
- Exogenous amyloid-β promotes tonic PTH secretion in cultured murine and human parathyroid glands.
- Deletion of the App gene in parathyroid cells reduces tonic PTH secretion and lowers serum PTH levels in mice.
- Amyloid-β interacts with GABAB1R/CaSR heterodimers, influencing PTH secretion.
- Lower serum 25-hydroxyvitamin D levels correlate with increased GABAB1R/CaSR heterodimer expression and β-amyloidogenesis in hyperparathyroidism patients.
- Ablation of App or the Tau-encoding Mapt gene prevents tonic PTH hypersecretion in Vdr knockout mice.
- An amyloid-β-neutralizing antibody, combined with cinacalcet, effectively reduces serum PTH levels in aged mice.
- Targeting amyloid-β shows potential for treating hyperparathyroidism due to vitamin D deficiency.