Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise - PubMed
4 days ago
- #inflammation
- #mitochondrial transfer
- #NMN
- NMN supplementation shows anti-inflammatory effects in human skeletal muscle post BFR-exercise.
- Study involved 11 untrained men in a randomized, placebo-controlled crossover trial with NMN (1200 mg/d) for 7 days.
- NMN suppressed increases in TNF-α and IL-10 mRNA, indicating reduced inflammatory signaling.
- NMN delayed the rise in p21 mRNA, suggesting a delay in myogenic differentiation.
- Resolution of infiltrating cells from necrotic regions was moderately delayed by NMN.
- BFR-exercise increased mitochondrial content by 171% after 24h recovery, but NMN abolished this adaptation.
- Phagocytes carried more mitochondria than myofiber cytoplasm, forming a diffusion gradient toward damaged myofiber regions.
- NMN may suppress mitochondrial replenishment from phagocytes to repairing myofibers while inhibiting inflammation.