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Interim Estimates of 2025-26 Seasonal Influenza Vaccine Effectiveness - United States, September 2025-February 2026 - PubMed

7 hours ago
  • #public health
  • #vaccine effectiveness
  • #influenza
  • Interim influenza vaccine effectiveness (VE) estimates for the 2025-26 season were calculated using a test-negative case-control design.
  • Among children and adolescents (<18 years), VE was 38%-41% against outpatient visits and 41% against hospitalization.
  • Among adults (≥18 years), VE was 22%-34% against outpatient visits and 30% against hospitalization.
  • VE against influenza A ranged from 37%-42% in children/adolescents and 30%-34% in adults.
  • VE against influenza A(H3N2) was 35% (outpatient) and 38% (hospitalization) in children/adolescents.
  • VE against influenza B was 45%-71% in children/adolescents and 63% in adults.
  • CDC recommends influenza vaccination for all persons aged ≥6 months, as vaccines remain available.
  • Several authors disclosed institutional support, consulting fees, or participation in advisory boards related to vaccine research.