FGF4 initiates X-chromosome inactivation via activating YY1 and prompting loss of pluripotency factors - PubMed
4 hours ago
- #Embryonic Stem Cells
- #FGF4
- #X-chromosome inactivation
- FGF4 is essential for initiating X-chromosome inactivation (XCI) in mouse embryonic stem cells by upregulating Xist RNA.
- FGF4 acts through MEK/ERK signaling to activate YY1, a transcription activator of Xist, and promotes loss of pluripotency factors like Prdm14.
- Deficiency in Fgf4 or blocking FGFR prevents Xist upregulation and XCI initiation, linking differentiation signals to XCI.
- The FGF-ERK-YY1 axis connects YY1 activation to XCI, coordinating Xist expression with ESC differentiation.