Discontinuation of Beta-Blocker Therapy after Myocardial Infarction - PubMed
3 hours ago
- #Myocardial infarction
- #Secondary prevention
- #Beta-blocker therapy
- Beta-blocker discontinuation after myocardial infarction is noninferior to continuation in patients without left ventricular systolic dysfunction or heart failure.
- The trial involved 2540 patients with LVEF ≥40%, randomized 1:1 to discontinue or continue beta-blockers after at least 1 year of therapy post-MI.
- Primary endpoint was a composite of death, recurrent MI, or hospitalization for heart failure.
- At median 3.1 years follow-up, discontinuation group had 58 events vs. 74 in continuation group; hazard ratio 0.80, meeting noninferiority criteria.
- Incidence of serious adverse events was similar between groups, suggesting no excess risk from discontinuing beta-blockers.