Exosomal circ0000549 promotes MNNG‑induced gastric cancer through miR‑15b‑5p/KIF1B - PubMed
4 days ago
- #exosome
- #circ0000549
- #gastric cancer
- Exosomal circ0000549 is upregulated in MNNG-induced gastric cancer (GC) and promotes malignant transformation.
- Circ0000549 enhances malignant features in GES-1 cells and modulates epithelial-mesenchymal transition and stemness-related properties.
- Circ0000549 acts as a sponge for miR-15b-5p, leading to increased KIF1B expression and activation of the PI3K/AKT signaling pathway.
- Exosomal circ0000549 may serve as a biomarker for GC diagnosis and prognosis and a potential therapeutic target.