Nucleotide signals coordinate activation and inhibition of bacterial immunity - PubMed
4 days ago
- #nucleotide signaling
- #anti-phage defense
- #bacterial immunity
- Clover is a bacterial anti-phage defense system that dynamically responds to phage infection and inhibitory nucleotide signals.
- CloA, a dGTPase enzyme, is activated by viral enzymes increasing dTTP levels and inhibited by p3diT, a nucleotide signal synthesized by CloB.
- Cryo-EM structures reveal how dTTP and p3diT regulate CloA's function through distinct allosteric sites.
- The system balances antiviral defense and immune-mediated toxicity by coordinating activation and inhibition via nucleotide signals.