DefensePredictor: A machine learning model to discover prokaryotic immune systems - PubMed
3 hours ago
- #Machine Learning
- #Antiphage Defense
- #Prokaryotic Immunity
- DefensePredictor is a machine learning model that uses protein language model embeddings to classify proteins as defensive, aiming to discover prokaryotic immune systems beyond those found in defense islands.
- When applied to 69 diverse Escherichia coli strains, DefensePredictor predicted hundreds of previously unknown systems, with 42 validated experimentally, and analysis of 1000 prokaryotic genomes identified nearly 3000 novel protein clusters.
- The model facilitates comprehensive discovery of antiphage defense systems, which can reveal connections between prokaryotic and eukaryotic immunity and accelerate biotechnology development.