Mechanistic basis of plant hormone transport by ABC transporters: Insights from cryo-EM structures - PubMed
7 hours ago
- #hormone transport
- #cryo-EM
- #ABC transporter
- ABC transporters utilize ATP hydrolysis to transport diverse substrates across biological membranes.
- Recent cryo-EM advances have enabled the structural determination of plant hormone ABC transporters at 2-4 Å resolution.
- The review highlights structural insights into four plant ABC transporters: ABCG25 (abscisic acid exporter), ABCG16 (jasmonic acid exporter), ABCB19, and ABCB1 (brassinosteroid exporters).
- Structural determinants underlying functional divergence and substrate-binding pockets defining selectivity are identified.
- Mechanistic variations in ATPase activities and energy coupling mechanisms are detailed.
- Structural knowledge bridges the gap between hormone signaling and transporter function, offering potential for crop engineering.