Liver-Detargeted Aromatic Bioreducible mRNA Lipid Nanoparticles Confer Lymph Node Tropism and Robust Antigen-Specific Immunity - PubMed
4 hours ago
- #lipid nanoparticles
- #vaccine development
- #mRNA delivery
- Liver-detargeted aromatic bioreducible mRNA lipid nanoparticles (aroLNPs) were developed to enhance lymph node tropism and reduce liver accumulation.
- The LNPs utilize aromatic ionizable lipids with bioreducible disulfide bonds for improved transfection and biodegradability.
- A library of these lipids was created, varying amine core structure, lipid tail length, and regiochemistry.
- Top-performing aroLNPs demonstrated strong antigen-specific immune responses and increased effector memory T cell generation in preclinical SARS-CoV-2 vaccine studies.
- aroLNPs showed low systemic inflammatory cytokine levels and strong retention at the injection site.
- The platform holds promise for vaccine delivery and immune-focused therapeutic applications.