The fibrinogen αC region promotes arterial thrombosis in the context of hypofibrinogenemia - PubMed
4 days ago
- #arterial thrombosis
- #hypofibrinogenemia
- #fibrinogen
- Hypofibrinogenemia reduces venous thrombosis but its impact on arterial thrombosis was previously unknown.
- In a study of congenital fibrinogen disorders, 7% of patients developed arterial thrombosis, with 10% of hypofibrinogenemia cases affected.
- Patients with fibrinogen αC-region truncation mutations showed no arterial thrombosis over 286 patient-years.
- Mouse models were used to study hypofibrinogenemia and fibrinogen αC-region's role in arterial thrombosis.
- Hypofibrinogenemic mice with truncated αC-region (Fga270/270) showed suppressed arterial thrombosis, unlike controls.
- Depletion of platelet GPVI receptor protected wildtype mice from arterial thrombosis under mild but not severe FeCl3 challenge.
- The fibrinogen αC-region promotes arterial thrombosis specifically in hypofibrinogenemic conditions.