Inhibition of the NLRP3 Inflammasome With MCC950 Improves Gut Health in Huntington's Disease Mice - PubMed
8 hours ago
- #Huntington's disease
- #gut health
- #NLRP3 inflammasome
- Inhibition of NLRP3 inflammasome with MCC950 improved gut health in Huntington's disease mice.
- MCC950 treatment rescued gut abnormalities like increased fecal output and water content, and improved stool consistency.
- The treatment did not affect body/brain weight, cognitive/motor performance, or gut microbiota profile in HD mice.
- Targeting NLRP3 represents a promising therapeutic avenue for gastrointestinal issues in Huntington's disease.