The impact of antigen presentation on BBB disruption and neuroinflammation - PubMed
10 hours ago
- #Blood brain barrier
- #Neuroinflammation
- #Antigen presentation
- Blood brain barrier (BBB) disruption is a key complication in various neurological diseases, linking conditions like cerebral malaria, COVID-19, and Parkinson's disease.
- Neuroinflammation and immune cell infiltration both drive and result from BBB disruption, with T cell responses interacting with the neurovascular unit (NVU) in preclinical models.
- MHC class I and class II molecules on NVU cells regulate T cell entry, retention, and barrier disruption in neuroinflammatory diseases.
- Specific HLA genes are associated with neurological diseases featuring neuroinflammation and BBB disruption, highlighting the role of antigen presentation in neuropathology.