Endothelial Hippo pathway regulates the neutrophil niche and lung fibrosis - PubMed
3 hours ago
- #Hippo/YAP1
- #Lung Fibrosis
- #Neutrophil Recruitment
- The Hippo/YAP1 pathway in endothelial cells (ECs) plays a crucial role in lung fibrosis by regulating the neutrophil niche.
- YAP1 activation in ECs is observed in fibrotic lungs in both mice and humans, promoting fibrosis, while its deficiency reverses fibrosis.
- Endothelial YAP1 regulates CXCL1 expression, which recruits CXCR2+ neutrophils to injured lungs, contributing to fibrosis.
- Blocking neutrophil recruitment with a CXCR2 antagonist reduces lung fibrosis and counteracts the effects of YAP1 activation.
- Therapeutic inhibition of YAP1 with verteporfin decreases CXCL1 expression, neutrophil recruitment, and fibrosis, highlighting a potential treatment strategy.