Preventing Cisplatin-Induced Hearing Loss in Adults: A Systematic Review and Meta-Analysis - PubMed
6 days ago
- #hearing-loss
- #cisplatin
- #ototoxicity
- The study reviews interventions to prevent cisplatin-induced hearing loss in adults.
- Eight studies (431 patients) were analyzed, including six randomized control trials and two prospective cohort studies.
- Cytoprotective treatments included diethyldithiocarbamate, dexamethasone, N-acetylcysteine, sodium thiosulfate, calcium gluconate, and aspirin.
- No significant difference in hearing loss incidence was found between treatment (63.3%) and control (66.2%) groups.
- Dexamethasone showed lower hearing loss compared to N-acetylcysteine, but neither was superior to the control group.
- The study highlights the need for standardized ototoxicity grading scales and larger sample sizes for future research.