Distinct radial glia subtypes regulate midbrain dopaminergic neuron development - PubMed
5 days ago
- #Parkinson's disease
- #neuroscience
- #stem cells
- Distinct radial glia (Rgl) subtypes regulate midbrain dopaminergic (mesDA) neuron development.
- Rgl1 is identified as the progenitor of the mesDA lineage, with a transcriptional network coordinated by BMAL1.
- Rgl3 is a key signaling subtype that promotes the survival and yield of human stem cell-derived mesDA neurons.
- The study provides insights into lineage relationships in the developing ventral midbrain (VM).
- Findings could improve the derivation of clinically relevant human mesDA neurons for Parkinson's disease therapies.