OSBPL3 drives colorectal cancer progression via Hippo-YAP signaling and modulates MEK inhibitor sensitivity - PubMed
5 days ago
- #OSBPL3
- #colorectal cancer
- #Hippo-YAP signaling
- OSBPL3 drives colorectal cancer progression via Hippo-YAP signaling.
- Elevated OSBPL3 levels correlate with shortened patient survival.
- Depleting OSBPL3 impairs cancer cell proliferation and invasion, while overexpression accelerates tumor growth.
- OSBPL3 binds 14-3-3 proteins to promote YAP1 nuclear translocation, activating oncogenic pathways.
- High OSBPL3 expression leads to resistance to MEK inhibitors, overcome by YAP1 suppression or combined YAP/MEK inhibition.
- OSBPL3 is proposed as a therapeutic target for colorectal cancers with Hippo pathway alterations.