An enteric neuron ionotropic receptor regulates salt stress resistance - PubMed
3 hours ago
- #salt stress
- #ionotropic receptor
- #enteric neuron
- The I3 pharyngeal neuron in C. elegans detects salt via the GLR-9 ionotropic receptor and GLR-7 co-receptor, regulating salt stress tolerance.
- Salt sensation by I3 specifically protects against high-salt stress, not sugar solutions, with glr-9 mutants showing reduced hypertonic salt tolerance.
- I3 uses cholinergic signaling for acute salt stress tolerance and peptidergic signaling during acclimatization for resistance to subsequent high-salt challenges.
- Transcriptomic analyses reveal that I3 modulates salt tolerance by regulating salt stress response gene expression in distal tissues.
- Mutations in salt- and GLR-9-regulated genes reduce salt stress resistance, highlighting the pathway's role in physiological homeostasis.