Circadian oscillations in chromatin accessibility systematically orchestrate rhythmic gene transcription in soybean - PubMed
3 days ago
- #chromatin accessibility
- #soybean genetics
- #circadian rhythms
- Circadian oscillations in chromatin accessibility orchestrate rhythmic gene transcription in soybean.
- Integration of ATAC-seq, ChIP-seq, and RNA-seq maps the genome-wide circadian chromatin accessibility landscape.
- 11 core co-oscillation groups (CCOGs) identified with synchronized chromatin accessibility and mRNA oscillations.
- Accessible chromatin regions (ACRs) in CCOGs enriched for binding motifs of core circadian oscillators.
- Two distinct ACRs regulate circadian rhythmicity and stable expression of GmLHY1a.
- Natural variants of ACRs correlate with soybean latitudinal adaptation.
- Mutations in core oscillator components disrupt chromatin oscillation in CCOGs.
- Mechanism revealed where chromatin accessibility rhythms orchestrate transcriptional programs.
- Provides multi-omics resource for crop breeding and environmental adaptation.