Nonoxidative pentose phosphate pathway regulates CD8+ T cell immunity by maintaining NADPH homeostasis - PubMed
a day ago
- #NADPH
- #nonoxidative pentose phosphate pathway
- #CD8+ T cell
- The nonoxidative pentose phosphate pathway (non-oxPPP) is crucial for CD8+ T cell activation, proliferation, and memory formation by maintaining NADPH homeostasis.
- Metabolomic profiling showed upregulated non-oxPPP flux in effector (Teff) and memory (Tm) CD8+ T cells, enhancing NADPH yield and metabolic fitness.
- Inhibition of transketolase (TKT) or transaldolase (TALDO1) impaired NADPH production, leading to oxidative stress, reduced lipid synthesis, and compromised T cell function.
- Enhancing non-oxPPP activity promoted memory T cell differentiation, persistence, and recall responses.
- Targeting the non-oxPPP could improve cancer immunotherapy and vaccine efficacy by boosting T cell responses.