Cytosol-dwelling bacteria engage in a ubiquitination race to avoid antibacterial autophagy - PubMed
6 hours ago
- #Ubiquitination
- #Shigella
- #Autophagy
- Host cells use antibacterial autophagy to fight bacteria, relying on ubiquitination to mark pathogens for degradation.
- RNF213 is an E3 ligase that ubiquitinates lipopolysaccharides on cytosolic bacteria, targeting them for autophagy.
- Shigella flexneri avoids this by using IpaH1.4, an effector protein that ubiquitinates and degrades RNF213 via the proteasome.
- Cryo-EM studies show IpaH1.4 binds the RING domain of RNF213, and it may target other immune-related E3 ligases.