Bacterial enzyme-responsive hydrogels for triggered delivery of antibiotics to infected wounds - PubMed
3 hours ago
- #antibiotic-delivery
- #hydrogel
- #wound-infection
- Bacterial enzyme-responsive hydrogels are developed for targeted antibiotic delivery to infected wounds.
- The hydrogel uses a β-lactamase-cleavable crosslinker, degrading in the presence of β-lactamase-producing bacteria to release antibiotics.
- Ciprofloxacin-loaded liposomes are encapsulated within the hydrogel, ensuring on-demand release only at infection sites.
- Demonstrated effectiveness in ex vivo and in vivo models, including complete bacterial eradication in a murine skin abrasion model.
- Outperformed a commercial silver-based hydrogel in wound healing and bacterial eradication.
- The hydrogel did not induce ciprofloxacin resistance in non-β-lactamase-producing bacteria.
- Potential to improve treatment of wound infections and reduce antimicrobial resistance.