MSC-mimicking nanovesicle embedded bio-adhesive hydrogel for dual immunomodulation and osteogenesis to promote maxillofacial bone regeneration - PubMed
a day ago
- #bone regeneration
- #tissue engineering
- #immunomodulation
- Development of a bio-adhesive hydrogel (PEG-pp@nMSC@MT) embedded with MSC-mimicking nanovesicles for maxillofacial bone regeneration.
- The hydrogel features robust adhesive strength, biocompatibility, and resistance to masticatory forces in the oral cavity.
- Incorporation of an MMP2-cleavable peptide enables inflammation-responsive, on-demand release of nanovesicles and attenuation of excessive MMP2 activity.
- Therapeutic melatonin is efficiently delivered to BMMSCs, enhancing osteogenic and immunomodulatory functions.
- Synergistic effects include reduction of MMP2, secretion of anti-inflammatory factors, and promotion of M2 macrophage polarization.
- Demonstrated superior biodegradability and osteo-inductive capacity compared to Bio-Oss, a current clinical standard.
- Represents a promising all-in-one therapeutic strategy combining immunomodulation and cell-specific targeting for bone defect repair.