Association Between Sarcopenia and Frailty Transition in Chinese Older Adults: A Multistate Markov Model Study - PubMed
7 hours ago
- #sarcopenia
- #geriatric health
- #frailty
- The study examines the association between sarcopenia and frailty transitions in Chinese older adults using a multistate Markov model.
- Data from 4 waves (2011-2018) of the China Health and Retirement Longitudinal Study (CHARLS) was analyzed, involving 4621 participants aged ≥60 years.
- Frailty status was classified as robust, prefrailty, or frailty using a 35-item frailty index, while sarcopenia was defined based on AWGS 2019 criteria.
- Results showed that sarcopenia, regardless of severity, was associated with frailty progression, with confirmed sarcopenia having HRs of 1.29 (robust to prefrailty) and 1.20 (prefrailty to frailty).
- Low muscle strength was the strongest sarcopenia component associated with frailty deterioration, followed by low physical performance.
- The findings highlight the importance of early screening and targeted interventions for sarcopenia to mitigate frailty progression in older adults.