Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan - PubMed
3 hours ago
- #Hypoxia
- #Aging
- #HIF-1α
- The intervertebral disc (IVD) exhibits slow aging, linked to its persistently hypoxic environment and degradation of HIF-1α via optineurin-mediated selective autophagy.
- A small-molecule compound, HIF-1α-targeting autophagy-tethering compound (HATC), was developed to extend this protective mechanism to other tissues.
- Weekly systemic HATC administration in aged mice reduced HIF-1α levels, ameliorated age-related pathologies, and extended median (~14%) and maximum (~12%) lifespan.