Multi-omics reveals heterogeneity and functional populations of oligodendrocyte progenitor cells induced by human neural stem cells - PubMed
8 hours ago
- #oligodendrocyte progenitor cells
- #myelination
- #single-cell RNA sequencing
- Study identifies three distinct subclusters of human oligodendrocyte progenitor cells (hOPCs): PRE-OPCs, OPCs, and PRE-OLs.
- PDGFR-α+ hOPCs show enhanced myelination, migration, and proliferation compared to unsorted and PDGFR-α- hOPCs.
- Enhanced functions of PDGFR-α+ hOPCs may be linked to PI3K-AKT-mTOR and TGF-β signaling pathways.
- hOPCs were induced by human neural stem cells (hNSCs) and characterized using RNA-Scope and single-cell RNA sequencing.
- The study was approved by relevant ethics committees, with no competing interests declared by the authors.