Specialized high-capacity mitochondria fuel cell invasion - PubMed
4 hours ago
- #ATP production
- #cell invasion
- #mitochondria
- Specialized mitochondria in C. elegans anchor cell localize to basement membrane breaching site.
- These high-capacity mitochondria have enriched electron transport chain components and dense cristae.
- Formation depends on AC specification and pro-invasive transcriptional program.
- Netrin signaling via Src kinase directs microtubule polarization for mitochondrial trafficking.
- High ATP production from these mitochondria fuels energetically intensive cell invasion.