Dual Roles of CCN5/WISP2 in Cytosol and Secretome for Maintaining Muscle Homeostasis and Preventing Sarcopenia - PubMed
6 hours ago
- #CCN5/WISP2
- #Sarcopenia
- #Mitochondrial Function
- CCN5/WISP2 expression decreases in the early stages of sarcopenia, indicating potential as a diagnostic biomarker.
- Knockdown of CCN5 in mice and cells leads to sarcopenia-like symptoms, including muscle dysfunction, fat accumulation in muscle, and impaired mitochondrial function.
- CCN5 promotes mitochondrial biogenesis and lipid droplet-mitochondria interactions via secreted and intracellular pathways, enhancing lipid oxidation and reducing myosteatosis.
- Overexpression of CCN5 in aged mice improves muscle function, reduces fat accumulation, and restores mitochondrial health, suggesting therapeutic potential for sarcopenia.