Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia - PubMed
10 hours ago
- #antipsychotic effects
- #Rho-kinase inhibitor
- #schizophrenia
- ARHGAP10 gene variations linked to schizophrenia negatively regulate RhoA/ROCK signaling; selective ROCK2 inhibitor KD025 showed antipsychotic-like effects in mouse models.
- KD025 reduced abnormal phosphorylation and improved spine density in medial prefrontal cortex neurons, and mitigated cognitive and motor impairments induced by methamphetamine and MK-801.
- At effective doses, KD025 did not cause common antipsychotic side effects like extrapyramidal symptoms, hyperprolactinemia, or hyperglycemia in mice, indicating a favorable safety profile.