Alisol B as a novel inhibitor of TβRs suppresses the growth and metastasis of non-small cell lung cancer by inhibiting TGF-β-induced epithelial-mesenchymal transition - PubMed
10 hours ago
- #non-small cell lung cancer
- #epithelial-mesenchymal transition
- #TGF-β receptors
- Alisol B (ALB) inhibits TGF-β1-induced proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in lung adenocarcinoma cells.
- ALB directly binds to ATP-binding sites of TGF-β receptors (TGFβR1 and TGFβR2), promoting TGFβR2 degradation and suppressing downstream signaling pathways.
- In vivo studies show ALB suppresses tumor growth and lung metastasis in mouse models of non-small cell lung cancer (NSCLC).