Matrix Metalloproteinase 7 Mediates Epithelial-Mesenchymal Transition to Promote Liver Fibrosis Through E-cadherin/β-catenin Pathway in Biliary Atresia - PubMed
4 hours ago
- #biliary atresia
- #liver fibrosis
- #MMP7
- MMP7 is positively correlated with liver fibrosis in biliary atresia (BA) patients.
- Gene set enrichment analysis (GSEA) links MMP7 to epithelial-mesenchymal transition (EMT) in biliary epithelial cells (BECs).
- MMP7 induces EMT in BECs by cleaving E-cadherin and promoting β-catenin nuclear translocation.
- Blocking MMP7 alleviates EMT and liver fibrosis in a chronic BA mouse model.
- Targeting MMP7 shows potential as an anti-fibrotic therapy in BA.